Xingdong Zhang Selected Research

Durapatite (Hydroxylapatite)

12/2022	Construction of a magnesium hydroxide/graphene oxide/hydroxyapatite composite coating on Mg-Ca-Zn-Ag alloy to inhibit bacterial infection and promote bone regeneration.
1/2022	Nano-hydroxyapatite-evoked immune response synchronized with controllable immune adjuvant release for strengthening melanoma-specific growth inhibition.
11/2021	Exposure to hydroxyapatite nanoparticles enhances Toll-like receptor 4 signal transduction and overcomes endotoxin tolerance in vitro and in vivo.
11/2019	Effect of surface microstructure on the anti-fibrosis/adhesion of hydroxyapatite ceramics in spinal repair of rabbits.
1/2019	Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect.
1/2019	The in vitro and in vivo anti-melanoma effects of hydroxyapatite nanoparticles: influences of material factors.
1/2018	Antitumor Effect by Hydroxyapatite Nanospheres: Activation of Mitochondria-Dependent Apoptosis and Negative Regulation of Phosphatidylinositol-3-Kinase/Protein Kinase B Pathway.
2/2017	Cellular internalization of rod-like nano hydroxyapatite particles and their size and dose-dependent effects on pre-osteoblasts.
1/2017	A multi-level comparative analysis of human femoral cortical bone quality in healthy cadavers and surgical safe margin of osteosarcoma patients.
8/2015	[Inhibitory Effect of Hydroxyapatite Particles with Different Size on Malignant Melanoma A375 Cells: A Preliminary Study].

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Xingdong Zhang Research Topics

Disease

27	Neoplasms (Cancer) 01/2022 - 09/2013
7	Inflammation (Inflammations) 01/2022 - 01/2017
7	Breast Neoplasms (Breast Cancer) 11/2020 - 09/2013
5	Neoplasm Metastasis (Metastasis) 11/2020 - 09/2013
4	Wounds and Injuries (Trauma) 01/2022 - 07/2011
4	Stress Fractures (Stress Fracture) 01/2022 - 01/2021
3	Melanoma (Melanoma, Malignant) 01/2022 - 08/2015
3	Osteoporosis 01/2021 - 01/2016
3	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 06/2014
3	Carcinoma (Carcinomatosis) 07/2015 - 09/2010
2	Bacterial Infections (Bacterial Infection) 12/2022 - 01/2021
2	Infections 01/2022 - 08/2020
2	Bone Resorption 08/2020 - 06/2007
2	Fibrosis (Cirrhosis) 11/2019 - 11/2012
2	Osteosarcoma (Osteogenic Sarcoma) 10/2017 - 09/2012
2	Fatigue 03/2015 - 06/2007
1	Osteolysis 12/2022
1	Giant Cell Tumors (Giant Cell Tumor) 01/2022
1	Osteoarthritis 01/2022
1	Hyperplasia 01/2021
1	Neointima 01/2021
1	Persistent Infection 08/2020
1	Necrosis 08/2020
1	Triple Negative Breast Neoplasms 07/2020
1	Thrombosis (Thrombus) 01/2020
1	Cicatrix (Scar) 11/2019
1	Splenomegaly 10/2019
1	Residual Neoplasm 10/2019
1	Ulcer 10/2019
1	Stomach Ulcer (Gastric Ulcer) 10/2019
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2019

Drug/Important Bio-Agent (IBA)

15	Pharmaceutical PreparationsIBA 01/2021 - 09/2010
12	Durapatite (Hydroxylapatite)IBA 12/2022 - 02/2004
9	CollagenIBA 01/2022 - 02/2004
9	HydrogelsIBA 01/2022 - 07/2011
9	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2020 - 09/2013
8	MicellesIBA 01/2021 - 09/2010
7	Biocompatible Materials (Biomaterials)IBA 01/2022 - 02/2004
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2019
5	pullulanIBA 02/2017 - 07/2011
4	PolymersIBA 01/2021 - 02/2004
4	Therapeutic UsesIBA 01/2021 - 07/2015
3	calcium phosphateIBA 01/2022 - 01/2020
3	Biological ProductsIBA 11/2021 - 07/2015
3	Lapatinib (GW572016)FDA Link 11/2020 - 07/2020
3	Polysaccharides (Glycans)IBA 11/2020 - 07/2011
2	SolutionsIBA 01/2022 - 10/2019
2	poly(lactide) (polylactic acid)IBA 01/2021 - 01/2020
2	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 11/2020 - 07/2020
2	AcidsIBA 11/2020 - 07/2020
2	Anti-Bacterial Agents (Antibiotics)IBA 08/2020 - 10/2019
2	GlycerophosphatesIBA 10/2019 - 04/2019
2	ChitosanIBA 10/2019 - 04/2019
2	Drug CarriersIBA 07/2017 - 12/2013
2	Asialoglycoprotein ReceptorIBA 07/2015 - 06/2014
1	AlloysIBA 12/2022
1	graphene oxideIBA 12/2022
1	Magnesium Hydroxide (Brucite)FDA Link 12/2022
1	Denosumab FDA Link 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	AntigensIBA 01/2022
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2022
1	VaccinesIBA 11/2021
1	polyetheretherketoneIBA 01/2021
1	HydrazonesIBA 01/2021
1	Hyaluronic Acid (Hyaluronan)IBA 11/2020
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2020
1	2,3-dimethylmaleic anhydrideIBA 10/2020
1	Lysine (L-Lysine)FDA Link 10/2020
1	Amino Acids FDA Link 10/2020
1	Biopolymers (Biopolymer)IBA 10/2020
1	StrontiumIBA 08/2020
1	Bone Cements (Bone Glue)IBA 08/2020
1	ProdrugsIBA 07/2020
1	CytokinesIBA 01/2020
1	hydroxyapatite-beta tricalcium phosphateIBA 01/2020
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020
1	MagnesiumIBA 01/2020
1	liposomal doxorubicin (Doxil)FDA Link 10/2019
1	salinomycinIBA 10/2019
1	Antineoplastic Agents (Antineoplastics)IBA 10/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	TitaniumIBA 01/2019
1	CarbonIBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 01/2022 - 12/2013
9	Therapeutics 01/2022 - 07/2015
2	Combination Drug Therapy (Combination Chemotherapy) 10/2019 - 11/2015
2	Nanospheres 01/2019 - 01/2018
2	Precision Medicine 06/2018 - 05/2018
1	Curettage 01/2022
1	Lasers (Laser) 01/2022
1	Replacement Arthroplasty 01/2022
1	Stents 01/2021
1	Microspheres (Microsphere) 01/2021
1	Osteotomy 08/2020
1	External Fixators 08/2020
1	Molecular Targeted Therapy 07/2020
1	Laminectomy 11/2019
1	Catheters 10/2019